![]() From an industrial perspective, this work also corroborates that the scale-up to a continuous process using a mesostructured reactor, NETmix, from a batch laboratorial process is feasible without impacting stability. Results indicate no significant differences related to the used production method. A clear tendency to aggregation and coalescence was observed for high temperatures (70–90 ✬). Pickering emulsions undergo complete phase separation at very low pH (2) due to n-HAp particle's disruption. In general, and despite the droplet size, the n-HAp Pickering emulsions were stable within the tested ionic strength range, at relatively high pH environments (6–10), and at temperatures up to 70 ✬. Droplet size, morphology, and zeta-potential were analysed after 1 and 7 days under storage. In this work, hydroxyapatite nanoparticles (n-HAp) Pickering emulsions produced in continuous mode using a mesostructured reactor (average size ~ 7, 11 and 18 µm) and in batch mode using a rotor–stator device (average size ~ 18 µm) were studied concerning their behaviour at different temperatures (5–90 ✬), pH (2–10) and ionic strength (0–500 mM), conditions with relevance for food applications. Having in view their effective use it is important to study their stability against environmental stresses impacting manufacture, storage, and application conditions. Oil-in-water (O/W) Pickering emulsions are attracting attention as carriers of lipophilic active compounds with clear advantages over traditional systems.
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